In an interview he gave in 1966, Martin Heidegger spoke about precisely this experience. Heidegger is arguably the most influential philosopher of the 20th century; he is inarguably the most controversial. His thinking on what it means to be human in a technologically advanced world still informs debates on genetics, medicine and artificial intelligence today. He was also a Nazi. You just have to deal with this sort of thing in contemporary philosophy.
Heidegger had a reaction different from mine. "I was certainly shocked when I recently saw photographs of the Earth taken from the moon," he said. He fears estrangement; I fear liking it. For Heidegger, if you want to destroy humanity, you don't need nuclear weapons or a giant asteroid or pollution or disease, you just need to convince people that they live on a planet rather than on the ground. The image of the Earth from space is something we cannot accept without becoming inhuman. I pretty much live for ideas like that.
Science fiction always takes a position on Heidegger. Star Wars, Star Trek, old Battlestar Galactica and Mass Effect all believe Heidegger was wrong. They believe humanity can endure among the stars. Theirs is a humanist sci-fi.
Others are transhumanist. They agree with Heidegger without necessarily siding with him. They tell us we cannot go out into space and remain human. The stars are too many and the void between them too dark. But that's OK. We don't need to be human. Heidegger was right about humanity's limits but wrong about the implications of exceeding them. The most important question of our time may be "Should we lose our humanity?" Mass Effect scares me by making me want to say "yes."
